Perineal wound closure using gluteal turnover flap or primary closure after abdominoperineal resection for rectal cancer: a randomised controlled multicenter trial
The role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer, a multicenter randomized phase III study.
Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases CAIRO5 a randomized phase 3 study of the Dutch Colorectal Cancer Group (DCCG)
Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC Dutch randomized multicentre trial.
Pelvic Floor Rehabilitation to improve functional Outcome and quality of life after surgery for Rectal CancEr: a randomized controlled trial.
A phase III study of first-line Pembrolizumab (MK-3475) versus chemotherapy in microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal carcinoma
Neo-adjuvant FOLFOXIRI and chemoradiotherapy for high risk (“ugly”) locally advanced rectal cancer
Randomized Multicentre Phase III study of short course radiation therapy followed by prolonged pre-operative chemotherapy and surgery in primary high risk rectal cancer compared to standard chemoradiotherapy and surgery and optional adjuvant chemotherapy.
Can we Save the rectum by Watchful waiting or TransAnal microsurgery following (chemo)Radiotherapy versus Total mesorectal excision for early Rectal Cancer?
An open-label, randomised, phase 2 study comparing S 95005 plus bevacizumab to capecitabine plus bevacizumab in patients with previously untreated metastatic colorctal cancer who are non-eligible for intensive therapy