Acronym
PLCRC-PROTECT
Name of the study
The PLCRC-PROTECT study: Dietary intake after diagnosis and colorectal cancer outcomes
Researchers and contact information
Contact information Project Manager
Dr. H.W.G. (Jeroen) Derksen, Postdoctoral researcher
Julius Center for Health Sciences and Primary Care
UMC Utrecht
PO Box 85500 (mailroom Str. 6.131), 3508 GA Utrecht
Email: h.w.g.derksen-2@umcutrecht.nl
Contact information Principal Investigators
Prof. dr. M. (Miriam) Koopman, Medical oncologist
Dept. of Medical Oncology
UMC Utrecht
PO Box 85500 (mailroom Q05.4.300), 3508 GA Utrecht
Email: m.koopman-6@umcutrecht.nl
Prof. dr. A.M. (Anne) May, Epidemiologist
Julius Center for Health Sciences and Primary Care
UMC Utrecht
PO Box 85500 (mailroom Str. 6.131), 3508 GA Utrecht
Email: a.m.may@umcutrecht.nl
Study team
06-46919566
Website
Summary study
Rationale: In contrast to the extensive knowledge about the role of dietary factors on the primary risk of CRC, little is known about its relation with clinical CRC outcomes. This prospective study in CRC patients investigates the relation between (changes in) dietary patterns and dietary supplement use during cancer treatment and clinical outcomes such as treatment-related toxicities, recurrence, progression and survival.
Objective:
Primary:
- To investigate the association between (changes in) diet and CRC survival in patients diagnosed with stage I-IV CRC.
Secondary, including but not limited to:
- Changes in habitual dietary intake/patterns in the first two years post-diagnosis in patients diagnosed with stage I-IV CRC, with special focus on total energy, macronutrients, fiber, meat, fish, dairy, alcohol, and fruit and vegetable intake.
- The association of (changes in) dietary intake with treatment-related toxicity, disease progression and/or recurrence in patients treated for stage I-IV CRC.
- The association between (changes in) dietary supplement use and treatment-related toxicity and treatment outcomes in patients treated for stage I-IV CRC.
- If (changes in) dietary intake before and after diagnosis is related to quality of life in patients diagnosed with stage I-IV CRC.
- If (changes in) dietary intake before and after diagnosis is related to the body composition of patients diagnosed with stage I-IV CRC.
Study design: Prospective observational cohort study. Participants will be asked to complete a general demographics-, a food frequency-, dietary supplement- and a sensory-questionnaire soon after diagnosis, and at 6, 12 and 24 months post-diagnosis.
Study population: 1,000 recently diagnosed stage I-IV CRC patients, age ≥ 18 years, who are enrolled in the PLCRC cohort. In all participating hospitals, recently diagnosed stage I-IV CRC patients who are included in the PLCRC cohort will be screened and invited (if applicable preferably before chemo- or radiotherapy) to participate in the PLCRC-PROTECT study.
Intervention
Participating centers
- UMC Utrecht
- Flevo Ziekenhuis, Almere
- St Antonius Ziekenhuis, Nieuwegein
- Deventer Ziekenhuis, Deventer
- Diakonessenhuis, Utrecht
- Ziekenhuis Rivierenland, Tiel
- Spaarne Gasthuis, Haarlem
- IJsselland Ziekenhuis, Capelle aan den IJssel
- Treant Zorggroep, Hoogeveen
- Rode Kruis Ziekenhuis, Beverwijk
- Reinier de Graaf Gasthuis, Delft
- Haaglanden MC, Den Haag
- Haga ziekenhuis, Den Haag
- Antonius Ziekenhuis, Sneek
- Wilhelmina Ziekenhuis, Assen
- Bravis Ziekenhuis, Roosendaal
- ZorgSaam, Terneuzen
- Van Weel Bethesda Ziekenhuis, Dirksland
- Alrijne Ziekenhuis, Alphen aan de Rijn
- Bernhoven, Oss
- Canisius Wilhelmina Ziekenhuis, Nijmegen